{"id":3256,"date":"2022-10-07T16:42:38","date_gmt":"2022-10-07T16:42:38","guid":{"rendered":"http:\/\/www.brandon.ddtest.info\/gochemless\/?page_id=3256"},"modified":"2022-10-07T16:56:38","modified_gmt":"2022-10-07T16:56:38","slug":"helicobacter","status":"publish","type":"page","link":"http:\/\/www.brandon.ddtest.info\/gochemless\/helicobacter\/","title":{"rendered":"Helicobacter"},"content":{"rendered":"<p>[vc_row tm_bgimagefixed=&#8221;&#8221; css=&#8221;.vc_custom_1665065727174{margin-top: 4px !important;margin-bottom: 0px !important;border-top-width: 4px !important;border-bottom-width: 0px !important;padding-top: 4px !important;padding-bottom: 0px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_single_image image=&#8221;3287&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_outline&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row][vc_row tm_bgimagefixed=&#8221;&#8221; css=&#8221;.vc_custom_1665065701088{margin-top: 0px !important;margin-bottom: 0px !important;border-top-width: 0px !important;border-bottom-width: 0px !important;padding-top: 0px !important;padding-bottom: 0px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_separator][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row][vc_row tm_bgimagefixed=&#8221;&#8221; css=&#8221;.vc_custom_1665004846055{margin-top: 4px !important;border-top-width: 4px !important;padding-top: 4px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><strong>Helicobacter pylori is a Gram-negative bacterium that colonizes the gut mucosa and can induce gastric ulcers. In an Advanced Online Publication in\u00a0<\/strong><a href=\"http:\/\/www.nature.com\/naturegenetics\" target=\"_blank\" rel=\"noopener\"><strong>Nature Genetics<\/strong><\/a><strong>, Akihiro Fujikawa and colleagues report how the H. pylori cytotoxin\u00a0<\/strong><a href=\"http:\/\/www.biomedcentral.com\/pubmed\/8163943\" target=\"_blank\" rel=\"noopener\"><strong>VacA<\/strong><\/a><strong>causes ulcer formation (Nature Genetics, DOI:10.1038\/ng1112, 24 February, 2003).<\/strong><\/p>\n<p style=\"text-align: justify;\">Bacterial induced stomach ulcers can benefit from colloidal silver mineral water.<\/p>\n<div style=\"text-align: justify;\"><\/div>\n<div style=\"text-align: justify;\"><strong>Bacterial cytotoxin induces the epithelial cell detachment that leads to ulcer formation.<\/strong><\/div>\n<div style=\"text-align: justify;\">By Jonathan Weitzman<\/div>\n<div style=\"text-align: justify;\"><\/div>\n<div style=\"text-align: justify;\">Helicobacter pylori is a Gram-negative bacterium that colonizes the gut mucosa and can induce gastric ulcers. In an Advanced Online Publication in\u00a0<a href=\"http:\/\/www.nature.com\/naturegenetics\" target=\"_blank\" rel=\"noopener\">Nature Genetics<\/a>, Akihiro Fujikawa and colleagues report how the H. pylori cytotoxin\u00a0<a title=\"VacA\" href=\"http:\/\/www.biomedcentral.com\/pubmed\/8163943\" target=\"_blank\" rel=\"noopener\">VacA<\/a>\u00a0causes ulcer formation (Nature Genetics, DOI:10.1038\/ng1112, 24 February, 2003).<\/div>\n<div style=\"text-align: justify;\"><\/div>\n<div style=\"text-align: justify;\">Mice lacking the Prptz gene \u2014 encoding a protein tyrosine phosphatase receptor type 2 expressed in gastric glands \u2014 are resistant to VacA-induced ulcers. VacA is taken up equally well by epithelial cells, in culture or in vivo, in the absence of Prptz, with no differences in vacuole development or cell survival. However, VacA binding to Ptprz initiates a signaling cascade that leads to cell detachment from the basement membrane. In addition, this can be mimicked with an endogenous Ptprz ligand that was also found to induce severe gastritis.\u00a0These findings indicate potential novel clinical strategies including Colloidal Silver based on inhibiting the VacA-Ptprz pathway or downstream events that lead to cell detachment and subsequent gastritis.<\/div>\n<div style=\"text-align: justify;\"><\/div>\n<div style=\"text-align: justify;\"><\/div>\n<div style=\"text-align: justify;\">Article links:<\/div>\n<div style=\"text-align: justify;\">A. Fujikawa et al., \u201cMice deficient in protein tyrosine kinase phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori,\u201d Nature Genetics, DOI:10.1038\/ng1112, 24 February, 2003.<br \/>\n<a href=\"http:\/\/www.nature.com\/naturegenetics\" target=\"_blank\" rel=\"noopener\">http:\/\/www.nature.com\/naturegenetics\u00a0<\/a>J.L. Telford et al., \u201cGene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease,\u201d Journal of Experimental Medicine, 179:1653-1658, 1994.<br \/>\n[<a href=\"http:\/\/www.biomedcentral.com\/pubmed\/8163943\" target=\"_blank\" rel=\"noopener\">PubMed Abstract<\/a>]<\/div>\n<div style=\"text-align: justify;\"><\/div>\n<div style=\"text-align: justify;\"><\/div>\n<div style=\"text-align: justify;\"><strong>News From The Medical World<\/strong><strong>:\u00a0<\/strong><strong>TheSYNAPSE<\/strong><\/div>\n<div style=\"text-align: justify;\">\n<p>Penn State Harrisburg researchers report they have found the first direct link between the presence of a bacterium in Pennsylvania drinking water and stomach ulcers.The research team headed by Katherine H. Baker, assistant professor of environmental microbiology, revealed this week it has tied Helicobacter pylori in well water and clinical infection in persons drinking from that supply. Helicobacter pylori is an organism linked to the cause of at least 75 percent of all stomach ulcers and two types of stomach cancers.<\/p>\n<\/div>\n<p style=\"text-align: justify;\"><strong>MIGRAINES caused by\u00a0Helicobacter pylori:<\/strong><\/p>\n<div>\n<p style=\"text-align: justify;\">Tuesday, April 30, 2002Milan, Italy \u2014 \u201cSome headaches may be linked to infection with a common bug and daily doses of friendly bacteria could ward them off, preliminary research suggests.\u00a0A study presented last week at an infectious diseases conference found that about 18 per cent of chronic migraine sufferers were infected with the stomach bug Helicobacter pylori, and antibiotics appeared to clear the headaches.\u00a0Other studies suggest a link to endocardial damage and heart attacks.<\/p>\n<p style=\"text-align: justify;\">Adding the friendly bacteria Lactobacillus seemed to work even better, leaving most people migraine-free for a year and lessening the intensity and frequency of recurring headaches in the others, the lead researcher said\u201d.\u00a0Colloidal silver should also be helpful.<\/p>\n<\/div>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row tm_bgimagefixed=&#8221;&#8221; css=&#8221;.vc_custom_1665065727174{margin-top: 4px !important;margin-bottom: 0px !important;border-top-width: 4px !important;border-bottom-width: 0px !important;padding-top: 4px !important;padding-bottom: 0px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_single_image image=&#8221;3287&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_outline&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row][vc_row tm_bgimagefixed=&#8221;&#8221; css=&#8221;.vc_custom_1665065701088{margin-top: 0px !important;margin-bottom: 0px !important;border-top-width: 0px !important;border-bottom-width: 0px !important;padding-top: 0px !important;padding-bottom: 0px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_separator][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row][vc_row tm_bgimagefixed=&#8221;&#8221; css=&#8221;.vc_custom_1665004846055{margin-top: 4px !important;border-top-width: 4px !important;padding-top: 4px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_column_text] Helicobacter pylori is a Gram-negative bacterium &hellip; <a href=\"http:\/\/www.brandon.ddtest.info\/gochemless\/helicobacter\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Helicobacter<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/www.brandon.ddtest.info\/gochemless\/wp-json\/wp\/v2\/pages\/3256"}],"collection":[{"href":"http:\/\/www.brandon.ddtest.info\/gochemless\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.brandon.ddtest.info\/gochemless\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.brandon.ddtest.info\/gochemless\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.brandon.ddtest.info\/gochemless\/wp-json\/wp\/v2\/comments?post=3256"}],"version-history":[{"count":4,"href":"http:\/\/www.brandon.ddtest.info\/gochemless\/wp-json\/wp\/v2\/pages\/3256\/revisions"}],"predecessor-version":[{"id":3288,"href":"http:\/\/www.brandon.ddtest.info\/gochemless\/wp-json\/wp\/v2\/pages\/3256\/revisions\/3288"}],"wp:attachment":[{"href":"http:\/\/www.brandon.ddtest.info\/gochemless\/wp-json\/wp\/v2\/media?parent=3256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}